JAK-STAT signaling in asthma

The Jak-Stat Signaling Pathway of Interferons System: Snapshots

Interferons (IFNs) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. Although IFNs have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. IFNs exert their pleiotropic effects through their multisubunit cell surface recept...

SnapShot: JAK-STAT Signaling

JAK-STAT Signaling: From Interferons

Published, JBC Papers in Press, May 14, DOI 10.1074/jbc.R700016200 Christian Schindler, David E. Levy, and Thomas Decker From the Departments of Microbiology andMedicine, Columbia University, New York, New York 10032, Departments of Pathology and Microbiology, New York University School of Medicine, New York, New York 10016, and Max F. Perutz Laboratories, Department of Microbiology and Immunob...

The JAK/STAT signaling pathway.

The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. JAK activation stimulates cell prolifer...

JAK-STAT signaling in human disease

Numerous examples indicate that mammalian development can be entirely normal in the absence of the immune system; indeed, prior to birth, individuals with even very severe immunodeficiencies are developmentally unaffected. Perhaps it is not surprising, therefore, that more than 95 different primary immunodeficiency syndromes have been identified, encompassing defects in lymphocytes, phagocytes,...